Biomaterials Utilizing Cell Adhesion

Cell Adhesion to Biomaterials: Concept of Biocompatibility

Electrospun polycaprolactone/ZnO nanocomposite membranes as biomaterials with antibacterial and cell adhesion properties

In the present study we have investigated the effect of zinc oxide (ZnO) nanoparticles on the fiber diameter, fiber morphology, antibacterial activity, and enhanced cell proliferation of the electrospun polycaprolactone (PCL) non-woven membrane. The effect of the ZnO nanoparticle concentration on the fiber diameter and fiber morphology was investigated using a scanning electron microscope (SEM)...

Preimplantation processing of ex vivo-derived vascular biomaterials: effects on peripheral cell adhesion.

The use of ex vivo-derived scaffolds as vascular conduits has shown to be a clinically valid approach to repair or bypass occluded vessels. Implantation of allogeneic tissue grafts requires careful processing to lower immunogenicity and prevent bacterial infection. However, the mechanical/chemical treatments used to prepare biological scaffolds can result in significant alterations to the nativ...

PEG-variant biomaterials as selectively adhesive protein templates: model surfaces for controlled cell adhesion and migration.

Our study focused on the role of poly(ethylene glycol) (PEG) in actively regulating the biological responsiveness of protein-adsorbed biomaterials. To this end, we designed PEG-variant biomaterials from a family of tyrosine/PEG-derived polycarbonates to present surfaces ranging from low to intermediate levels of PEG concentration, below the PEG level requisite for complete abolition of protein ...

Light-triggered in vivo Activation of Adhesive Peptides Regulates Cell Adhesion, Inflammation and Vascularization of Biomaterials

Materials engineered to elicit targeted cellular responses in regenerative medicine must display bioligands with precise spatial and temporal control. Although materials with temporally regulated presentation of bioadhesive ligands using external triggers, such as light and electric fields, have recently been realized for cells in culture, the impact of in vivo temporal ligand presentation on c...